With therapeutic doses of TCAs, barbiturates enhance metabolism and reduce blood concentrations of TCAs.
pentobarbital will minimize the level or effect of dutasteride by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Not known.
Coadministration of zuranolone with other CNS depressants might maximize impairment of psychomotor performance or CNS depressant outcomes. If unavoidable, take into account dose reduction. .
pentobarbital will minimize the level or effect of vardenafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
benzhydrocodone/acetaminophen and pentobarbital equally maximize sedation. Avoid or Use Alternate Drug. Limit use to people for whom substitute treatment method options are inadequate
pentobarbital will minimize the extent or influence of lopinavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will lessen the extent or outcome of eletriptan by influencing hepatic/intestinal enzyme CYP3A4 Nembutal metabolism. Use Caution/Check.
Observe Carefully (1)pentobarbital will decrease the extent or outcome of cannabidiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
With therapeutic doses of TCAs, barbiturates raise metabolism and reduce blood concentrations of TCAs.
Comment: Barbiturates may well increase adverse outcomes, such as respiratory depression, produced by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.
pentobarbital will reduce the extent or result of isavuconazonium sulfate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
Contraindicated. Coadministration of lorlatinib with strong CYP3A inducers is contraindicated. Discontinue the robust CYP3A inducer for three plasma fifty percent-life before initiating lorlatinib.
lasmiditan, pentobarbital. Possibly improves consequences of one other by sedation. Use Caution/Keep track of. Coadministration of lasmiditan and various CNS depressant prescription drugs, such as alcohol have not been evaluated in medical studies. Lasmiditan might cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
Contraindicated (one)pentobarbital will lower the extent or result of fostemsavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism.